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Mutations in the β-tubulin binding site for peloruside A confer resistance by targeting a cleft significant in side chain binding
Peloruside A is a microtubule-stabilizing macrolide that binds to β-tubulin at a site distinct from the taxol site. The site was previously identified by H-D exchange mapping and molecular docking as a region close to the outer surface of the microtubule and confined in a cavity surrounded by a cont...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Landes Bioscience
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3233629/ https://ncbi.nlm.nih.gov/pubmed/21926482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.19.17706 |
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