A Unique Mode of Microtubule Stabilization Induced by Peloruside A

Microtubules are a significant therapeutic target for the treatment of cancer, where suppression of microtubule dynamicity by drugs such as paclitaxel forms the basis of clinical efficacy. Peloruside A, a macrolide isolated from New Zealand marine sponge Mycale hentscheli, is a microtubule stabilizi...

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Main Authors: Huzil, J. Torin, Chik, John. K., Slysz, Gordon W., Freedman, Holly, Tuszynski, Jack, Taylor, Richard E., Sackett, Dan L., Schriemer, David C.
格式: Artigo
語言:Inglês
出版: 2008
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2441936/
https://ncbi.nlm.nih.gov/pubmed/18405918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.03.026
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