Onset and Progression of Behavioral and Molecular Phenotypes in a Novel Congenic R6/2 Line Exhibiting Intergenerational CAG Repeat Stability

In the present study we report on the use of speed congenics to generate a C57BL/6J congenic line of HD-model R6/2 mice carrying 110 CAG repeats, which uniquely exhibits minimal intergenerational instability. We also report the first identification of the R6/2 transgene insertion site. The relativel...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Cowin, Randi-Michelle, Bui, Nghiem, Graham, Deanna, Green, Jennie R., Grueninger, Stephan, Yuva-Paylor, Lisa A., Syed, Arsalan U., Weiss, Andreas, Paylor, Richard
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233565/
https://ncbi.nlm.nih.gov/pubmed/22163300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028409
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars