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Genetic reduction of muscarinic M(4) receptor modulates analgesic response and acoustic startle response in a mouse model of Fragile × Syndrome (F×S)
INTRODUCTION: The G-protein coupled muscarinic acetylcholine receptors, widely expressed in the CNS, have been implicated in Fragile × Syndrome (F×S). Recent studies have reported an overactive signaling through the muscarinic receptors in the Fmr1KO mouse model. Hence, it was hypothesized that redu...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3264832/ https://ncbi.nlm.nih.gov/pubmed/22123412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbr.2011.11.018 |
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