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Genetic reduction of group 1 metabotropic glutamate receptors alters select behaviors in a mouse model for fragile X syndrome

INTRODUCTION: Genetic heterogeneity likely contributes to variability in the symptoms among individuals with fragile X syndrome (FXS). Studies in the Fmr1 knockout (KO) mouse model for FXS suggest that excessive signaling through group I metabotropic glutamate receptors (Gp1 mGluRs), comprised of su...

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Bibliografische gegevens
Hoofdauteurs: Thomas, Alexia M., Bui, Nghiem, Graham, Deanna, Perkins, Jennifer R., Yuva-Paylor, Lisa A., Paylor, Richard
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142659/
https://ncbi.nlm.nih.gov/pubmed/21571007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbr.2011.04.049
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