Prolonged Epileptiform Discharges Induced by Altered Group I Metabotropic Glutamate Receptor-Mediated Synaptic Responses in Hippocampal Slices of a Fragile X Mouse Model

Mutations in FMR1, which encodes the fragile X mental retardation protein (FMRP), are the cause of fragile X syndrome (FXS), an X-linked mental retardation disorder. Inactivation of the mouse gene Fmr1 confers a number of FXS-like phenotypes including an enhanced susceptibility to epileptogenesis du...

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Vydáno v:J Neurosci
Hlavní autoři: Chuang, Shih-Chieh, Zhao, Wangfa, Bauchwitz, Robert, Yan, Qijiang, Bianchi, Riccardo, Wong, Robert K. S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2005
Témata:
Neurobiology of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725444/
https://ncbi.nlm.nih.gov/pubmed/16135762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1777-05.2005
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