Onset and Progression of Behavioral and Molecular Phenotypes in a Novel Congenic R6/2 Line Exhibiting Intergenerational CAG Repeat Stability

In the present study we report on the use of speed congenics to generate a C57BL/6J congenic line of HD-model R6/2 mice carrying 110 CAG repeats, which uniquely exhibits minimal intergenerational instability. We also report the first identification of the R6/2 transgene insertion site. The relativel...

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Hlavní autoři: Cowin, Randi-Michelle, Bui, Nghiem, Graham, Deanna, Green, Jennie R., Grueninger, Stephan, Yuva-Paylor, Lisa A., Syed, Arsalan U., Weiss, Andreas, Paylor, Richard
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233565/
https://ncbi.nlm.nih.gov/pubmed/22163300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028409
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