Pazopanib, A Multitargeted Tyrosine Kinase Inhibitor, Reduces Diabetic Retinal Vascular Leukostasis and Leakage

OBJECTIVE: To determine the efficacy of pazopanib eye drops in the streptozotocin induced diabetic retinopathy rat model. METHODS: A 0.5 % w/v pazopanib suspension was prepared in phosphate buffered saline (PBS, pH 7.4) in the presence of 0.5 % w/v sodium carboxymethyl cellulose. Brown Norway rats w...

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Hlavní autoři: Thakur, Ashish, Scheinman, Robert I., Rao, Vidhya R., Kompella, Uday B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233473/
https://ncbi.nlm.nih.gov/pubmed/21945644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mvr.2011.09.001
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