Target Cell-Mediated Editing of HIV-1 cDNA by APOBEC3 Proteins in Human Macrophages

Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) proteins are encapsidated by assembling HIV-1 virions and edit viral cDNA in the next round of infection. Using alpha interferon (IFN-α)-treated monocyte-derived macrophages, we show that infrequent editing of HIV-1 reverse...

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Bibliographic Details
Main Authors: Koning, Fransje A., Goujon, Caroline, Bauby, Hélène, Malim, Michael H.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233168/
https://ncbi.nlm.nih.gov/pubmed/21957290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00775-11
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