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A Critical Role of Mitochondrial Phosphatase Ptpmt1 in Embryogenesis Reveals a Mitochondrial Metabolic Stress-Induced Differentiation Checkpoint in Embryonic Stem Cells

Mitochondria are highly dynamic organelles that play multiple roles in cells. How mitochondria cooperatively modulate embryonic stem (ES) cell function during development is not fully understood. Global disruption of Ptpmt1, a mitochondrial Pten-like phosphatidylinositol phosphate (PIP) phosphatase,...

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Autors principals: Shen, Jinhua, Liu, Xia, Yu, Wen-Mei, Liu, Jie, Groot Nibbelink, Milou, Guo, Caiying, Finkel, Toren, Qu, Cheng-Kui
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233018/
https://ncbi.nlm.nih.gov/pubmed/21986498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05629-11
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