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A Critical Role of Mitochondrial Phosphatase Ptpmt1 in Embryogenesis Reveals a Mitochondrial Metabolic Stress-Induced Differentiation Checkpoint in Embryonic Stem Cells

Mitochondria are highly dynamic organelles that play multiple roles in cells. How mitochondria cooperatively modulate embryonic stem (ES) cell function during development is not fully understood. Global disruption of Ptpmt1, a mitochondrial Pten-like phosphatidylinositol phosphate (PIP) phosphatase,...

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Hlavní autoři: Shen, Jinhua, Liu, Xia, Yu, Wen-Mei, Liu, Jie, Groot Nibbelink, Milou, Guo, Caiying, Finkel, Toren, Qu, Cheng-Kui
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233018/
https://ncbi.nlm.nih.gov/pubmed/21986498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05629-11
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