A Combination Vaccine Consisting of Three Live Attenuated Enterotoxigenic Escherichia coli Strains Expressing a Range of Colonization Factors and Heat-Labile Toxin Subunit B Is Well Tolerated and Immunogenic in a Placebo-Controlled Double-Blind Phase I Trial in Healthy Adults

Immune responses against colonization factors (CFs) and the nontoxic B component of the enterotoxigenic Escherichia coli (ETEC) heat-labile toxin (LTB) are considered to be important for immunity against diarrhea caused by ETEC. Individual live attenuated ETEC derivatives that have had their toxin g...

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Autori principali: Harro, Clayton, Sack, David, Bourgeois, A. Louis, Walker, R., DeNearing, Barbara, Feller, Andrea, Chakraborty, Subhra, Buchwaldt, Charlotte, Darsley, Michael J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2011
Soggetti:
Vaccine Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232709/
https://ncbi.nlm.nih.gov/pubmed/21994354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.05342-11
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