The Oral, Live Attenuated Enterotoxigenic Escherichia coli Vaccine ACE527 Reduces the Incidence and Severity of Diarrhea in a Human Challenge Model of Diarrheal Disease

An oral, live attenuated, three-strain recombinant bacterial vaccine, ACE527, was demonstrated to generate strong immune responses to colonization factor and toxin antigens of enterotoxigenic Escherichia coli (ETEC) in human volunteers. The vaccine was safe and well tolerated at doses of up to 10(11...

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Detalhes bibliográficos
Main Authors: Darsley, Michael J., Chakraborty, Subhra, DeNearing, Barbara, Sack, David A., Feller, Andrea, Buchwaldt, Charlotte, Bourgeois, A. Louis, Walker, Richard, Harro, Clayton D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535858/
https://ncbi.nlm.nih.gov/pubmed/23035175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00364-12
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