Refinement of a Human Challenge Model for Evaluation of Enterotoxigenic Escherichia coli Vaccines

Enterotoxigenic Escherichia coli (ETEC) strain H10407 (serotype O78:H11 producing heat-labile toxin [LT], heat-stable toxin [ST], and colonization factor I [CFA/I]) induces reliably high diarrheal attack rates (ARs) in a human challenge model at doses of ≥10(9) CFU. A descending-dose challenge study...

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Bibliographic Details
Main Authors: Harro, Clayton, Chakraborty, Subhra, Feller, Andrea, DeNearing, Barbara, Cage, Alicia, Ram, Malathi, Lundgren, Anna, Svennerholm, Ann-Mari, Bourgeois, August L., Walker, Richard I., Sack, David A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
Subjects:
Vaccine Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187035/
https://ncbi.nlm.nih.gov/pubmed/21852546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.05194-11
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