Impact of lower challenge doses of enterotoxigenic Escherichia coli on clinical outcome, intestinal colonization and immune responses in adult volunteers

A reliable and effective human challenge model is needed to help down-select the most promising ETEC vaccines currently under development. Such a model would need to reliably induce diarrhea in a high proportion of volunteers using the lowest possible inoculum to maximize safety and sensitivity. Pre...

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Veröffentlicht in:PLoS Negl Trop Dis
Hauptverfasser: Chakraborty, Subhra, Harro, Clayton, DeNearing, Barbara, Brubaker, Jessica, Connor, Sean, Maier, Nicole, Dally, Len, Flores, Jorge, Bourgeois, A. Louis, Walker, Richard, Sack, David A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5942845/
https://ncbi.nlm.nih.gov/pubmed/29702652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0006442
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