The Oral, Live Attenuated Enterotoxigenic Escherichia coli Vaccine ACE527 Reduces the Incidence and Severity of Diarrhea in a Human Challenge Model of Diarrheal Disease

An oral, live attenuated, three-strain recombinant bacterial vaccine, ACE527, was demonstrated to generate strong immune responses to colonization factor and toxin antigens of enterotoxigenic Escherichia coli (ETEC) in human volunteers. The vaccine was safe and well tolerated at doses of up to 10(11...

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Bibliografiska uppgifter
Huvudupphovsmän: Darsley, Michael J., Chakraborty, Subhra, DeNearing, Barbara, Sack, David A., Feller, Andrea, Buchwaldt, Charlotte, Bourgeois, A. Louis, Walker, Richard, Harro, Clayton D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2012
Ämnen:
Vaccines
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535858/
https://ncbi.nlm.nih.gov/pubmed/23035175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00364-12
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