Evaluation of the Safety, Tolerability, and Immunogenicity of an Oral, Inactivated Whole-Cell Shigella flexneri 2a Vaccine in Healthy Adult Subjects

Shigella causes high morbidity and mortality worldwide, but there is no licensed vaccine for shigellosis yet. We evaluated the safety and immunogenicity of a formalin-inactivated whole-cell Shigella flexneri 2a vaccine, Sf2aWC, given orally to adult volunteers. In a double-blind, placebo-controlled...

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Detalhes bibliográficos
Publicado no:Clin Vaccine Immunol
Main Authors: Chakraborty, Subhra, Harro, Clayton, DeNearing, Barbara, Bream, Jay, Bauers, Nicole, Dally, Len, Flores, Jorge, Van de Verg, Lillian, Sack, David A., Walker, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820506/
https://ncbi.nlm.nih.gov/pubmed/26865592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00608-15
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