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Transgenic Analysis of the Role of FKBP12.6 in Cardiac Function and Intracellular Calcium Release
FK506 binding protein12.6 (FKBP12.6) binds to the Ca(2+) release channel ryanodine receptor (RyR2) in cardiomyocytes and stabilizes RyR2 to prevent premature sarcoplasmic reticulum Ca(2+) release. Previously, two different mouse strains deficient in FKBP12.6 were reported to have different abnormal...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Mary Ann Liebert, Inc.
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3232634/ https://ncbi.nlm.nih.gov/pubmed/22087651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2011.0411 |
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