Mutations in the E1a gene of adenovirus type 5 alter the tumorigenic properties of transformed cloned rat embryo fibroblast cells.

The adenovirus type 5 mutants H5hr1 and H5dl101 contain modifications in the E1a gene affecting the 13S mRNA-encoded 289-amino acid polypeptide and exhibit a cold-sensitive transformation phenotype upon infection of cloned rat embryo fibroblast (CREF) cells. Transformed cell lines expressing solely...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Babiss, L E, Liaw, W S, Zimmer, S G, Godman, G C, Ginsberg, H S, Fisher, P B
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1986
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323252/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2938185/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.7.2167
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