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Pyruvate is the source of the two carbons that are required for formation of the imidazoline ring of 4-demethylwyosine

TYW1 catalyzes the condensation of N-methylguanosine with two carbon atoms from an unknown second substrate to form 4-demethylwyosine, which is a common intermediate in the biosynthesis of all of the hypermodified RNA bases related to wybutosine found in eukaryal and archaeal tRNA(Phe). Of potential...

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Detalles Bibliográficos
Main Authors: Young, Anthony P., Bandarian, Vahe
Formato: Artigo
Idioma:Inglês
Publicado: 2011
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232322/
https://ncbi.nlm.nih.gov/pubmed/22026549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2015053
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