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Pyruvate is the source of the two carbons that are required for formation of the imidazoline ring of 4-demethylwyosine
TYW1 catalyzes the condensation of N-methylguanosine with two carbon atoms from an unknown second substrate to form 4-demethylwyosine, which is a common intermediate in the biosynthesis of all of the hypermodified RNA bases related to wybutosine found in eukaryal and archaeal tRNA(Phe). Of potential...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3232322/ https://ncbi.nlm.nih.gov/pubmed/22026549 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2015053 |
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