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Telomere shortening alters the kinetics of the DNA damage response after ionizing radiation in human cells

Studies of telomerase-deficient mice and human cell lines have demonstrated that telomere shortening enhances sensitivity to ionizing radiation (IR). The molecular basis for this observation remains unclear. To better understand the connection between telomere shortening and radiation sensitivity, w...

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Detalhes bibliográficos
Main Authors: Drissi, Rachid, Wu, Jing, Hu, Yafang, Bockhold, Carol, Dome, Jeffrey S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232288/
https://ncbi.nlm.nih.gov/pubmed/21930799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-11-0069
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