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Correlation of Inter-Locus Polyglutamine Toxicity with CAG•CTG Triplet Repeat Expandability and Flanking Genomic DNA GC Content
Dynamic expansions of toxic polyglutamine (polyQ)-encoding CAG repeats in ubiquitously expressed, but otherwise unrelated, genes cause a number of late-onset progressive neurodegenerative disorders, including Huntington disease and the spinocerebellar ataxias. As polyQ toxicity in these disorders in...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2011
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3232215/ https://ncbi.nlm.nih.gov/pubmed/22163004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028260 |
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