Sustained Local Delivery of siRNA from an Injectable Scaffold

Controlled gene silencing technologies have significant, unrealized potential for use in tissue regeneration applications. The design described herein provides a means to package and protect siRNA within pH-responsive, endosomolytic micellar nanoparticles (si-NPs) that can be incorporated into nonto...

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Bibliographic Details
Main Authors: Nelson, Christopher E., Gupta, Mukesh K., Adolph, Elizabeth J., Shannon, Joshua M., Guelcher, Scott A., Duvall, Craig L.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232066/
https://ncbi.nlm.nih.gov/pubmed/22061489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2011.10.033
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