Local delivery of PHD2 siRNA from ROS-degradable scaffolds to promote diabetic wound healing

siRNA delivered from ROS-degradable tissue engineering scaffolds promotes diabetic wound healing in rats. Porous poly(thioketal-urethane) (PTK-UR) scaffolds implanted in diabetic wounds locally deliver siRNA that inhibits the expression of prolyl hydroxylase domain protein 2 (PHD2), thereby increasi...

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Veröffentlicht in:Adv Healthc Mater
Hauptverfasser: Martin, John R., Nelson, Christopher E., Gupta, Mukesh K., Yu, Fang, Sarett, Samantha M., Hocking, Kyle M., Pollins, Alonda C., Nanney, Lillian B., Davidson, Jeffrey M., Guelcher, Scott A., Duvall, Craig L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5152672/
https://ncbi.nlm.nih.gov/pubmed/27717176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adhm.201600820
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