Local delivery of PHD2 siRNA from ROS-degradable scaffolds to promote diabetic wound healing

siRNA delivered from ROS-degradable tissue engineering scaffolds promotes diabetic wound healing in rats. Porous poly(thioketal-urethane) (PTK-UR) scaffolds implanted in diabetic wounds locally deliver siRNA that inhibits the expression of prolyl hydroxylase domain protein 2 (PHD2), thereby increasi...

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Опубликовано в: :Adv Healthc Mater
Главные авторы: Martin, John R., Nelson, Christopher E., Gupta, Mukesh K., Yu, Fang, Sarett, Samantha M., Hocking, Kyle M., Pollins, Alonda C., Nanney, Lillian B., Davidson, Jeffrey M., Guelcher, Scott A., Duvall, Craig L.
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5152672/
https://ncbi.nlm.nih.gov/pubmed/27717176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adhm.201600820
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