Monophosphorylation of CD79a and b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy

Anergic B cells are characterized by impaired signaling and activation following aggregation of their antigen receptors (BCR). The molecular basis of this impairment is not understood. In studies reported here Src homology-2 (SH2)-containing inositol 5-phosphatase SHIP-1 and its adaptor Dok-1 were f...

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Hlavní autoři: O’Neill, Shannon K., Getahun, Andrew, Gauld, Stephen B., Merrell, Kevin T., Tamir, Idan, Smith, Mia J., Dal Porto, Joseph M., Li, Quan-Zhen, Cambier, John C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232011/
https://ncbi.nlm.nih.gov/pubmed/22078222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.10.011
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