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B-cell anergy: from transgenic models to naturally occurring anergic B cells?

Anergy, a condition in which cells persist in the periphery but are unresponsive to antigen, is responsible for silencing many self-reactive B cells. Loss of anergy is known to contribute to the development of autoimmune diseases, including systemic lupus erythematosus and type 1 diabetes. Multiple...

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Detalhes bibliográficos
Main Authors: Cambier, John C., Gauld, Stephen B., Merrell, Kevin T., Vilen, Barbara J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3714009/
https://ncbi.nlm.nih.gov/pubmed/17641666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nri2133
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