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Comparative Performance of Cell Life Span and Cell Transit Models for Describing Erythropoietic Drug Effects

Prolonged time delay in response to drug action is a common feature of hematological responses to pharmacotherapy such as erythropoiesis. The objective of this study was to compare the performance of two competing modeling approaches for delayed drug effects, mechanistic cell life span models, and s...

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Detalhes bibliográficos
Main Authors: Budha, Nageshwar R., Kovar, Andreas, Meibohm, Bernd
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3231865/
https://ncbi.nlm.nih.gov/pubmed/22005901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-011-9302-9
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