Sphingosine Kinase-1 Pathway Mediates High Glucose-Induced Fibronectin Expression in Glomerular Mesangial Cells

Diabetic nephropathy is characterized by accumulation of glomerular extracellular matrix proteins, such as fibronectin (FN). Here, we investigated whether sphingosine kinase (SphK)1 pathway is responsible for the elevated FN expression in diabetic nephropathy. The SphK1 pathway and FN expression wer...

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Bibliografski detalji
Glavni autori: Lan, Tian, Liu, Weihua, Xie, Xi, Xu, Suowen, Huang, Kaipeng, Peng, Jing, Shen, Xiaoyan, Liu, Peiqing, Wang, Lijing, Xia, Pu, Huang, Heqing
Format: Artigo
Jezik:Inglês
Izdano: Endocrine Society 2011
Teme:
Original Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3231833/
https://ncbi.nlm.nih.gov/pubmed/21998146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2011-0095
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