Sphingosine Kinase-1 Pathway Mediates High Glucose-Induced Fibronectin Expression in Glomerular Mesangial Cells

Diabetic nephropathy is characterized by accumulation of glomerular extracellular matrix proteins, such as fibronectin (FN). Here, we investigated whether sphingosine kinase (SphK)1 pathway is responsible for the elevated FN expression in diabetic nephropathy. The SphK1 pathway and FN expression wer...

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Bibliografiske detaljer
Main Authors: Lan, Tian, Liu, Weihua, Xie, Xi, Xu, Suowen, Huang, Kaipeng, Peng, Jing, Shen, Xiaoyan, Liu, Peiqing, Wang, Lijing, Xia, Pu, Huang, Heqing
Format: Artigo
Sprog:Inglês
Udgivet: Endocrine Society 2011
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3231833/
https://ncbi.nlm.nih.gov/pubmed/21998146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2011-0095
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