Sphingosine kinase 1 mediates AGEs-induced fibronectin upregulation in diabetic nephropathy

Activation of sphingosine kinase 1 (SphK1) signaling pathway mediates fibronectin (FN) upregulation in glomerular mesangial cells (GMCs) under high glucose (HG) condition. However, the roles of SphK1 in advanced glycation end products (AGEs)-induced DN have not been elucidated. Here we show that AGE...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Chen, Cheng, Gong, Wenyan, Li, Changzheng, Xiong, Fengxiao, Wang, Shaogui, Huang, Junying, Wang, Yu, Chen, Zhiquan, Chen, Qiuhong, Liu, Peiqing, Lan, Tian, Huang, Heqing
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2017
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5667989/
https://ncbi.nlm.nih.gov/pubmed/29108256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20205
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