Sphingosine Kinase-1 Pathway Mediates High Glucose-Induced Fibronectin Expression in Glomerular Mesangial Cells

Diabetic nephropathy is characterized by accumulation of glomerular extracellular matrix proteins, such as fibronectin (FN). Here, we investigated whether sphingosine kinase (SphK)1 pathway is responsible for the elevated FN expression in diabetic nephropathy. The SphK1 pathway and FN expression wer...

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Autori principali: Lan, Tian, Liu, Weihua, Xie, Xi, Xu, Suowen, Huang, Kaipeng, Peng, Jing, Shen, Xiaoyan, Liu, Peiqing, Wang, Lijing, Xia, Pu, Huang, Heqing
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2011
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3231833/
https://ncbi.nlm.nih.gov/pubmed/21998146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2011-0095
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