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Functional Implications of Structural Predictions for Alternative Splice Proteins Expressed in Her2/neu–Induced Breast Cancers

Alternative splicing allows a single gene to generate multiple mRNA transcripts, which can be translated into functionally diverse proteins. However, experimentally-determined structures of protein splice isoforms are rare, and homology modeling methods are poor at predicting atomic-level structural...

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Bibliografiske detaljer
Main Authors: Menon, Rajasree, Roy, Ambrish, Mukherjee, Srayanta, Belkin, Saveliy, Zhang, Yang, Omenn, Gilbert S.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230717/
https://ncbi.nlm.nih.gov/pubmed/22003824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr200772w
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