In silico discovery of novel Retinoic Acid Receptor agonist structures

BACKGROUND: Several Retinoic Acid Receptors (RAR) agonists have therapeutic activity against a variety of cancer types; however, unacceptable toxicity profiles have hindered the development of drugs. RAR agonists presenting novel structural and chemical features could therefore open new avenues for...

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Bibliographic Details
Main Authors: Schapira, Matthieu, Raaka, Bruce M, Samuels, Herbert H, Abagyan, Ruben
Format: Artigo
Language:Inglês
Published: BioMed Central 2001
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC32304/
https://ncbi.nlm.nih.gov/pubmed/11405897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-1-1
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