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Human small-cell lung cancers show amplification and expression of the N-myc gene.

We have found that 6 of 31 independently derived human small-cell lung cancer (SCLC) cell lines have 5- to 170-fold amplified N-myc gene sequences. The amplification is seen with probes from two separate exons of N-myc, which are homologous to either the second or the third exon of the c-myc gene. A...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Nau, M M, Brooks, B J, Carney, D N, Gazdar, A F, Battey, J F, Sausville, E A, Minna, J D
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1986
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323017/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2869482/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.4.1092
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