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CASPASE 8 inhibits programmed necrosis by processing CYLD

CASPASE 8 initiates apoptosis downstream of TNF death receptors by undergoing autocleavage and processing the executioner CASPASE 3(1). However, the dominant function of CASPASE 8 is to transmit a pro-survival signal that suppresses programmed necrosis (or necroptosis) mediated by RIPK1 and RIPK3(2–...

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Detalhes bibliográficos
Main Authors: O’Donnell, Marie Anne, Perez-Jimenez, Eva, Oberst, Andrew, Ng, Aylwin, Massoumi, Ramin, Xavier, Ramnik, Green, Douglas R., Ting, Adrian T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229661/
https://ncbi.nlm.nih.gov/pubmed/22037414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2362
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