The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response

On detecting viral RNAs, the RNA helicase retinoic acid-inducible gene I (RIG-I) activates the interferon regulatory factor 3 (IRF3) signalling pathway to induce type I interferon (IFN) gene transcription. How this antiviral signalling pathway might be negatively regulated is poorly understood. Micr...

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Bibliografiska uppgifter
Huvudupphovsmän: Friedman, Constantin S, O'Donnell, Marie Anne, Legarda-Addison, Diana, Ng, Aylwin, Cárdenas, Washington B, Yount, Jacob S, Moran, Thomas M, Basler, Christopher F, Komuro, Akihiko, Horvath, Curt M, Xavier, Ramnik, Ting, Adrian T
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2008
Ämnen:
Scientific Report
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529351/
https://ncbi.nlm.nih.gov/pubmed/18636086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.136
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