Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD

Retinoic acid-inducible gene I (RIG-I) plays important roles in pathogen recognition and antiviral signalling transduction. Here we show that syndecan-4 (SDC4) is a RIG-I-interacting partner identified in a yeast two-hybrid screen. We find that SDC4 negatively regulates the RIG-I-mediated antiviral...

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Vydáno v:Nat Commun
Hlavní autoři: Lin, Wei, Zhang, Jing, Lin, Haiyan, Li, Zexing, Sun, Xiaofeng, Xin, Di, Yang, Meng, Sun, Liwei, Li, Lin, Wang, Hongmei, Chen, Dahua, Sun, Qinmiao
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4906230/
https://ncbi.nlm.nih.gov/pubmed/27279133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11848
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