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Regulation of Signal Transduction by Enzymatically Inactive Antiviral RNA Helicase Proteins MDA5, RIG-I, and LGP2

Intracellular pattern recognition receptors MDA5, RIG-I, and LGP2 are essential components of the cellular response to virus infection and are homologous to the DEXH box subfamily of RNA helicases. However, the relevance of helicase activity in the regulation of interferon production remains elusive...

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Библиографические подробности
Главные авторы: Bamming, Darja, Horvath, Curt M.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2009
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665091/
https://ncbi.nlm.nih.gov/pubmed/19211564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807365200
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