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Enhanced anti-tumor efficacy of low dose etoposide with oncolytic herpes simplex virus in human glioblastoma stem cell xenografts

PURPOSE: Glioblastoma (GBM) inevitably recurs despite surgery, radiation and chemotherapy. A subpopulation of tumor cells, GBM stem cells (GSCs), has been implicated in this recurrence. The chemotherapeutic agent, etoposide is generally reserved for treating recurrent tumors, however its effectivene...

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Main Authors: Cheema, Tooba A., Kanai, Ryuichi, Kim, Geon Woo, Wakimoto, Hiroaki, Passer, Brent, Rabkin, Samuel D., Martuza, Robert L.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229640/
https://ncbi.nlm.nih.gov/pubmed/21976549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-1762
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