Recruitment of Oct4 Protein to UV-Damaged Chromatin in Embryonic Stem Cells

BACKGROUND: Oct4 is a specific marker of embryonic stem cell (ESC) pluripotency. However, little is known regarding how Oct4 responds to DNA damage. Here, we investigated whether Oct4 recognizes damaged chromatin in mouse ESCs stably expressing GFP-Oct4. These experiments should contribute to the kn...

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Autors principals: Bártová, Eva, Šustáčková, Gabriela, Stixová, Lenka, Kozubek, Stanislav, Legartová, Soňa, Foltánková, Veronika
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229488/
https://ncbi.nlm.nih.gov/pubmed/22164208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027281
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