Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas

Melanomas display poor response rates to adjuvant therapies because of their intrinsic resistance to proapoptotic stimuli. This study indicates that such resistance can be overcome, at least partly, through the targeting of eEF1A elongation factor with narciclasine, an Amaryllidaceae isocarbostyril...

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Hauptverfasser: Van Goietsenoven, Gwendoline, Hutton, Jenna, Becker, Jean-Paul, Lallemand, Benjamin, Robert, Francis, Lefranc, Florence, Pirker, Christine, Vandenbussche, Guy, Van Antwerpen, Pierre, Evidente, Antonio, Berger, Walter, Prévost, Martine, Pelletier, Jerry, Kiss, Robert, Goss Kinzy, Terri, Kornienko, Alexander, Mathieu, Véronique
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2010
Schlagworte:
Research Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229423/
https://ncbi.nlm.nih.gov/pubmed/20643906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-162263
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