Discovery, Optimization, and Pharmacological Characterization of Novel Heteroaroylphenylureas Antagonists of C-C Chemokine Ligand 2 Function

Through the application of TRAP(®) (Target-Related Affinity Profiling), we identified a novel class of heteroaroylphenylureas that inhibit human CCL2-induced chemotaxis of monocytes/macrophages both in vitro and in vivo. This inhibition was concentration-dependent and selective with regards to other...

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Xehetasun bibliografikoak
Egile Nagusiak: Laborde, Edgardo, Macsata, Robert W., Meng, Fanying, Peterson, Brian T., Robinson, Louise, Schow, Steve R., Simon, Reyna J., Xu, Hua, Baba, Kunihisa, Inagaki, Hideaki, Ishiwata, Yoshiro, Jomori, Takahito, Matsumoto, Yukiharu, Miyachi, Atsushi, Nakamura, Takashi, Okamoto, Masayuki, Handel, Tracy M., Bernard, Claude C. A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229226/
https://ncbi.nlm.nih.gov/pubmed/21341682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1012903
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