Discovery, Optimization, and Pharmacological Characterization of Novel Heteroaroylphenylureas Antagonists of C-C Chemokine Ligand 2 Function

Through the application of TRAP(®) (Target-Related Affinity Profiling), we identified a novel class of heteroaroylphenylureas that inhibit human CCL2-induced chemotaxis of monocytes/macrophages both in vitro and in vivo. This inhibition was concentration-dependent and selective with regards to other...

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Detalhes bibliográficos
Main Authors: Laborde, Edgardo, Macsata, Robert W., Meng, Fanying, Peterson, Brian T., Robinson, Louise, Schow, Steve R., Simon, Reyna J., Xu, Hua, Baba, Kunihisa, Inagaki, Hideaki, Ishiwata, Yoshiro, Jomori, Takahito, Matsumoto, Yukiharu, Miyachi, Atsushi, Nakamura, Takashi, Okamoto, Masayuki, Handel, Tracy M., Bernard, Claude C. A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229226/
https://ncbi.nlm.nih.gov/pubmed/21341682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1012903
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