Discovery, Optimization, and Pharmacological Characterization of Novel Heteroaroylphenylureas Antagonists of C-C Chemokine Ligand 2 Function

Through the application of TRAP(®) (Target-Related Affinity Profiling), we identified a novel class of heteroaroylphenylureas that inhibit human CCL2-induced chemotaxis of monocytes/macrophages both in vitro and in vivo. This inhibition was concentration-dependent and selective with regards to other...

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Main Authors: Laborde, Edgardo, Macsata, Robert W., Meng, Fanying, Peterson, Brian T., Robinson, Louise, Schow, Steve R., Simon, Reyna J., Xu, Hua, Baba, Kunihisa, Inagaki, Hideaki, Ishiwata, Yoshiro, Jomori, Takahito, Matsumoto, Yukiharu, Miyachi, Atsushi, Nakamura, Takashi, Okamoto, Masayuki, Handel, Tracy M., Bernard, Claude C. A.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2011
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229226/
https://ncbi.nlm.nih.gov/pubmed/21341682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1012903
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