Discovery, Optimization, and Pharmacological Characterization of Novel Heteroaroylphenylureas Antagonists of C-C Chemokine Ligand 2 Function

Through the application of TRAP(®) (Target-Related Affinity Profiling), we identified a novel class of heteroaroylphenylureas that inhibit human CCL2-induced chemotaxis of monocytes/macrophages both in vitro and in vivo. This inhibition was concentration-dependent and selective with regards to other...

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Bibliografski detalji
Glavni autori: Laborde, Edgardo, Macsata, Robert W., Meng, Fanying, Peterson, Brian T., Robinson, Louise, Schow, Steve R., Simon, Reyna J., Xu, Hua, Baba, Kunihisa, Inagaki, Hideaki, Ishiwata, Yoshiro, Jomori, Takahito, Matsumoto, Yukiharu, Miyachi, Atsushi, Nakamura, Takashi, Okamoto, Masayuki, Handel, Tracy M., Bernard, Claude C. A.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229226/
https://ncbi.nlm.nih.gov/pubmed/21341682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1012903
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