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Tuning a polar molecule for selective cytoplasmic delivery by a pH (Low) Insertion Peptide
Drug molecules are typically hydrophobic and small in order to traverse membranes to reach cytoplasmic targets, but we have discovered that more polar molecules can be delivered across using water-soluble, moderately hydrophobic membrane peptides of the pHLIP(®) (pH Low Insertion Peptide) family. De...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3229090/ https://ncbi.nlm.nih.gov/pubmed/22029270 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2009773 |
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