Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) in combination with the Apogossypol derivative BI-97C1 (Sabutoclax) improves therapeutic efficacy in low CAR colorectal cancer cells

Adenovirus (Ad)-based gene therapy represents a potentially viable strategy for treating colorectal cancer. The infectivity of serotype 5 adenovirus (Ad.5), routinely used as a transgene delivery vector, is dependent on Coxsackie-adenovirus receptors (CAR). CAR expression is downregulated in many ca...

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Autors principals: Azab, Belal, Dash, Rupesh, Das, Swadesh K., Bhutia, Sujit K., Shen, Xue-Ning, Quinn, Bridget A., Sarkar, Siddik, Wang, Xiang-Yang, Hedvat, Michael, Dmitriev, Igor P., Curiel, David T., Grant, Steven, Dent, Paul, Reed, John C., Pellecchia, Maurizio, Sarkar, Devanand, Fisher, Paul B.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228880/
https://ncbi.nlm.nih.gov/pubmed/21780116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.22947
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