Insulin action is blocked by a monoclonal antibody that inhibits the insulin receptor kinase.
Thirty-six monoclonal antibodies to the human insulin receptor were produced. Thirty-four bound the intracellular domain of the receptor beta subunit, the domain containing the tyrosine-specific kinase activity. Of these 34 antibodies, 33 recognized the rat receptor and 1 was shown to precipitate th...
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| Опубликовано в:: | Proc Natl Acad Sci U S A |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
1986
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC322851/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3455769/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.2.328 |
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