Insulin signaling is required for insulin’s direct and indirect action on hepatic glucose production

We and others have suggested that insulin predominantly acts indirectly to inhibit hepatic glucose production (HGP) via suppression of gluconeogenic precursors, FFAs, and glucagon. To test that hypothesis, we performed high-dose hyperinsulinemic-euglycemic clamps using [3-(3)H]-glucose in liver-spec...

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Bibliographic Details
Main Authors: Fisher, Simon J., Kahn, C. Ronald
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2003
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC151923/
https://ncbi.nlm.nih.gov/pubmed/12588884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200316426
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