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Insulin signaling is required for insulin’s direct and indirect action on hepatic glucose production

We and others have suggested that insulin predominantly acts indirectly to inhibit hepatic glucose production (HGP) via suppression of gluconeogenic precursors, FFAs, and glucagon. To test that hypothesis, we performed high-dose hyperinsulinemic-euglycemic clamps using [3-(3)H]-glucose in liver-spec...

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Sonraí bibleagrafaíochta
Foilsithe in:J Clin Invest
Príomhchruthaitheoirí: Fisher, Simon J., Kahn, C. Ronald
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: American Society for Clinical Investigation 2003
Ábhair:
Rochtain ar líne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151923/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12588884/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI16426
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